Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
نویسندگان
چکیده
BACKGROUND The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes. METHODS In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index <35 kg/m(2)) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study. RESULTS At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups. CONCLUSION Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.
منابع مشابه
مقایسه‌ی اثرات اینولین و اینولین غنی شده با الیگو فروکتوز بر شاخص‌های گلیسمی و فشارخون در زنان با دیابت نوع 2: یک کارآزمایی بالینی
Background and Objective: There is a high prevalence of chronic diseases such as type 2 diabetes in most populations. Therefore, interest in use of functional foods for the control of such diseases is of importance. The present study was designed to compare the effects of inulin and oligofructose-enriched inulin on glycemic indices and blood pressure in women with type 2 diabetes. Materials and...
متن کاملEffects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial.
BACKGROUND Type 2 diabetes mellitus, as a noncommunicable disease, is the main public health challenge in the 21st century. The prevalence of diabetes mellitus adjusted for the world population in Iran was 8% until the year 2010.Lipid levels are considered as important parameters to be evaluated, as high serum lipid levels are often reported as a complication in patients with diabetes mellitus....
متن کاملتأثیر مکمل یاری اینولین بر ظرفیت آنتی‌اکسیدانی تام، فعالیت آنزیم‌های گلوتاتیون پراکسیداز، سوپراکسید دیسموتاز و کاتالاز در بیماران دیابتی نوع 2
Background & Aims : Considering the high prevalence of oxidative stress and lower total antioxidant status in type 2 diabetic patients, the aim of the present study was to investigate the effects of inulin on total antioxidant capacity , glutathione peroxidase, superoxide dismutase and catalase activities in these patients. Materials & Methods : In this controlled, randomized clinical tri...
متن کاملاثر تخم شنبلیله بر فاکتورهای متابولیکی سرم و سطوحIntercellular adhesion molecule1))ICAM-1 در بیماران دیابتی نوع 2
Background and Objectives: Diabetes mellitus (DM) especially type2 is one of the main causes of morbidity in developing countries such as Iran. Recently, fenugreek seeds as medical plant have been considered for treatment of diabetes. Therefore, we conducted this study to evaluate the effects of fenugreek seeds on serum metabolic factors and ICAM-1 levels in type 2 diabetic patients. Materials ...
متن کاملDepression and Glycemic Control in Type II Diabetic Patients
Objective: Studies reported conflicting results’ regarding the status of depression and glycemic control in patients with type II diabetes(T2DM), therefore, this study was performed to determine the relationship between depression and glycemic control in T2DM patients. Materials and Methods: This cross-sectional study was performed on 150 T2DM patients referred to Yazd diabetes researc...
متن کامل